Structure–function analysis of SAP97, a modular scaffolding protein that drives dendrite growth
نویسندگان
چکیده
منابع مشابه
Structure-function analysis of SAP97, a modular scaffolding protein that drives dendrite growth.
Activation of AMPA receptors assembled with the GluA1 subunit can promote dendrite growth in a manner that depends on its direct binding partner, SAP97. SAP97 is a modular scaffolding protein that has at least seven recognizable protein-protein interaction domains. Several complementary approaches were employed to show that the dendrite branching promoting action of full length SAP97 depends on...
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Activity-dependent dendrite elaboration influences the pattern of interneuronal connectivity and network function. In the present study, we examined the mechanism by which the GluR1 subunit of AMPA receptors controls dendrite morphogenesis. GluR1 binds to SAP97, a scaffolding protein that is a component of the postsynaptic density, via its C-terminal 7 aa. We find that elimination of this inter...
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ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2015
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2015.02.011